TY - JOUR AU - Roy, Suchismita AU - Pradhan, Shrabani AU - Mandal, Shreya AU - Das, Koushik AU - Nandi, Dilip Kumar PY - 2018/08/23 Y2 - 2024/03/29 TI - Nephroprotective efficacy of Asparagus racemosus root extract on acetaminophen-induced renal injury in rats JF - Acta Biologica Szegediensis JA - Acta Biol Szeged VL - 62 IS - 1 SE - Articles DO - 10.14232/abs.2018.1.17-23 UR - https://abs.bibl.u-szeged.hu/index.php/abs/article/view/2939 SP - 17-23 AB - <p>Acetaminophen-induced renal necrosis and insufficiency occurs in patients with acetaminophen overdose. Renal failure is rapidly assuming epidemic proportions globally. In absence of reliable and effective nephroprotective drugs, strategies towards exploring alternative therapies for treatment of kidney diseases are essential. <em>Asparagus racemosus</em> is a medicinal plant used for treatment of various ailments. This research was undertaken to investigate the protective effect of ethanol fraction of <em>A. racemosus</em> roots extract in acetaminophen-induced uraemia and renal failure in rats. Rats were co-administered with acetaminophen injection and oral administration of <em>A.&nbsp;racemosus</em> roots extract in an attempt of protection against renal failure. Uremic biomarkers significantly decreased, and elevated levels of antioxidant enzymes were found, in the animals treated with ethanol fraction of <em>A. racemosus</em> when compared with acetaminophen treated uremic animals. Also, histology of kidneys showed control like structure in animals treated with this extract but severe damage in the uremic animals. HPLC analysis of the ethanol fraction of <em>A. racemosus</em> roots extract revealed eight compounds out of which one had a retention time near to the quercetin standard. It may be concluded that this extract of <em>A. racemosus</em> has therapeutically useful nephroprotective potential.</p> ER -